Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14435550 | 0.88 | ALDH1A1 (0.42) | ALDH1A1LMNASLC22A1ACHESLC22A2 | |
| SCHEMBL9729528 | 0.87 | ALDH1A1 (0.56) | ALDH1A1LMNASLC22A1ACHESLC22A2 | |
| SCHEMBL3634362 | 0.83 | ALDH1A1 (0.49) | ALDH1A1LMNASLC22A1ACHESLC22A2 | |
| SCHEMBL13655355 | 0.81 | ALDH1A1 (0.53) | ALDH1A1LMNASLC22A1ACHESLC22A2 | |
| SCHEMBL4940443 | 0.81 | KMT2A (0.59) | ALDH1A1LMNASLC22A1ACHESLC22A2 | |
| SCHEMBL474091 | 0.79 | ALDH1A1 (0.53) | ALDH1A1LMNASLC22A1ACHESLC22A2 | |
| SCHEMBL14694183 | 0.79 | ALDH1A1 (0.49) | ALDH1A1LMNASLC22A1ACHESLC22A2 | |
| SCHEMBL2835194 | 0.79 | ALDH1A1 (0.49) | ALDH1A1LMNASLC22A1ACHESLC22A2 | |
| SCHEMBL3634366 | 0.78 | CYP1A2 (0.51) | ALDH1A1LMNASLC22A1ACHESLC22A2 | |
| SCHEMBL10859240 | 0.78 | ALDH1A1 (0.41) | ALDH1A1LMNASLC22A1ACHESLC22A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110950807-B | Biaryl compound, preparation method thereof, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2023-03-03 | — | — | CN | disclosed |
| WO-2007096393-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2007-08-30 | — | — | WO | disclosed |
| EP-0311322-B1 | PYRIDINE OR PYRIDAZINE DERIVATIVES AS CARDIO-PROTECTIVE AGENTS AND FOR THE TREATMENT OF ISCHEMIC DISEASE, AND PROCESS FOR THEIR PREPARATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-21 | — | — | EP | disclosed |
| US-4990507-A | Cardiotonic agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-05 | — | — | US | disclosed |
| EP-0228845-B1 | N-CONTAINING HETEROCYCLIC COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-12-12 | — | — | EP | disclosed |
| US-4931453-A | CARDIOVASCULAR, HYPOTENSIVE AGENTS | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1990-06-05 | — | — | US | disclosed |
| CN-1041589-A | The preparation method who contains cardioprotective agent and the ischemic disease therapeutical agent and the compound of N-heterogeneous ring compound | FUJISAWA PHARMACEUTICAL CO (JP) | 1990-04-25 | — | — | CN | disclosed |
| US-4857527-A | HYPOTENSIVE, ANTISCHEMIC AGENT | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| US-4831030-A | FOR CEREBROVASCULAR DISEASES; HYPERTENSIVE AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-05-16 | — | — | US | disclosed |
| EP-0311322-A2 | Pyridine or pyridazine derivatives as cardio-protective agents and for the treatment of ischemic disease, and process for their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-12 | — | — | EP | disclosed |
| EP-0228845-A2 | N-containing heterocyclic compounds, processes for the preparation thereof and composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-07-15 | — | — | EP | disclosed |