Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9867501 | 0.94 | ALDH1A1 (0.35) | MCHR1ALDH1A1KDM4EMAPTLMNA | |
| Fumaric Acid SCHEMBL9867491 | 0.94 | ALDH1A1 (0.35) | MCHR1ALDH1A1KDM4EMAPTLMNA | |
| Fumaric Acid SCHEMBL9602842 | 0.93 | ALDH1A1 (0.34) | MCHR1ALDH1A1KDM4EMAPTLMNA | |
| Fumaric Acid SCHEMBL9602836 | 0.93 | ALDH1A1 (0.34) | MCHR1ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL9603147 | 0.90 | MCHR1 (0.35) | MCHR1ALDH1A1MAPTLMNAACHE | |
| SCHEMBL9866052 | 0.90 | MCHR1 (0.34) | MCHR1ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL9865906 | 0.88 | ALDH1A1 (0.33) | ALDH1A1KDM4EMAPTLMNAGAA | |
| SCHEMBL9602580 | 0.88 | MCHR1 (0.39) | MCHR1ALDH1A1KDM4EMAPTGAA | |
| Hydrochloric Acid SCHEMBL9602310 | 0.87 | S1PR1 (0.33) | ALDH1A1KDM4EMAPTLMNAGAA | |
| Iodide SCHEMBL9602456 | 0.87 | ALDH1A1 (0.33) | ALDH1A1KDM4EMAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | claimed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | claimed |
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |