Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9603147 | 0.88 | MCHR1 (0.35) | MCHR1MAPTALDH1A1TOP1ACHE | |
| SCHEMBL9602772 | 0.88 | MCHR1 (0.35) | MCHR1KDM4EMAPTALDH1A1GAA | |
| SCHEMBL9866052 | 0.87 | MCHR1 (0.34) | MCHR1KDM4EMAPTALDH1A1GAA | |
| SCHEMBL9603188 | 0.87 | MAPT (0.37) | KDM4ENPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL9868430 | 0.87 | TOP1 (0.35) | MCHR1NPC1RAB9AMAPK1TOP1 | |
| SCHEMBL9866334 | 0.87 | ALDH1A1 (0.38) | KDM4ENPC1RAB9AMAPTALDH1A1 | |
| Iodide SCHEMBL10445218 | 0.86 | ALDH1A1 (0.38) | KDM4ENPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL9866881 | 0.83 | MAPT (0.39) | KDM4ENPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL9865229 | 0.83 | TOP1 (0.35) | MCHR1MAPTALDH1A1GAAL3MBTL1 | |
| Fumaric Acid SCHEMBL9867491 | 0.82 | ALDH1A1 (0.35) | MCHR1KDM4ENPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |