Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5826470 | 0.82 | CYP2A6 (0.50) | CYP2A6ALOX5MAPTCMA1SLC6A2 | |
| SCHEMBL28679598 | 0.79 | ALOX5 (0.46) | CYP2A6ALOX5MAPTCMA1SLC6A2 | |
| SCHEMBL30061208 | 0.79 | CYP2A6 (0.46) | CYP2A6ALOX5MAPTCMA1SLC6A2 | |
| SCHEMBL15596088 | 0.79 | CYP2A6 (0.46) | CYP2A6ALOX5MAPTCMA1SLC6A2 | |
| SCHEMBL19682789 | 0.76 | ALOX5 (0.51) | CYP2A6ALOX5MAPTCMA1SLC6A2 | |
| SCHEMBL9281496 | 0.72 | ALOX5 (0.44) | CYP2A6ALOX5MAPTCMA1SLC6A2 | |
| SCHEMBL9634797 | 0.71 | ALDH1A1 (0.36) | CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL717441 | 0.71 | ALOX5 (0.54) | CYP2A6ALOX5MAPTCMA1SLC6A2 | |
| SCHEMBL6026188 | 0.71 | ALOX5 (0.46) | CYP2A6ALOX5MAPTCMA1SLC6A2 | |
| SCHEMBL13920405 | 0.68 | ALOX5 (0.42) | CYP2A6ALOX5MAPTCMA1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279263-B1 | INDOLE, BENZOFURAN, BENZOTHIOPHENE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-08-04 | — | — | EP | disclosed |
| US-4873259-A | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0279263-A2 | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1988-08-24 | — | — | EP | disclosed |