Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602093 | 0.91 | HRH3 (0.39) | HRH3ALDH1A1GAAKMT2ATOP1 | |
| Fumaric Acid SCHEMBL9602356 | 0.85 | HRH3 (0.37) | HRH3ALDH1A1GAAKMT2A | |
| Fumaric Acid SCHEMBL9602362 | 0.85 | HRH3 (0.37) | HRH3ALDH1A1GAAKMT2A | |
| SCHEMBL9602008 | 0.84 | ALDH1A1 (0.40) | HRH3ALDH1A1GAAKMT2A | |
| SCHEMBL9866493 | 0.82 | HRH3 (0.41) | HRH3ALDH1A1GAAKMT2ATOP1 | |
| SCHEMBL9601997 | 0.78 | HRH3 (0.39) | HRH3ALDH1A1GAAKMT2AMAPK14 | |
| SCHEMBL9601550 | 0.77 | HRH3 (0.40) | HRH3ALDH1A1GAAKMT2AMAPK14 | |
| SCHEMBL10365979 | 0.77 | ALDH1A1 (0.50) | HRH3ALDH1A1GAAKMT2A | |
| SCHEMBL9873107 | 0.76 | HRH3 (0.38) | HRH3ALDH1A1GAAKMT2AMAPK14 | |
| SCHEMBL9602165 | 0.76 | HRH3 (0.41) | HRH3ALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |