Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9602362 | 1.00 | HRH3 (0.37) | HRH3KMT2AALDH1A1GAATDP1 | |
| SCHEMBL9602093 | 0.93 | HRH3 (0.39) | HRH3KMT2AALDH1A1GAAMEN1 | |
| Fumaric Acid SCHEMBL9866109 | 0.89 | HRH3 (0.37) | HRH3KMT2AALDH1A1GAATDP1 | |
| Fumaric Acid SCHEMBL9603083 | 0.85 | MCHR1 (0.39) | HRH3KMT2AALDH1A1GAATDP1 | |
| Fumaric Acid SCHEMBL9603089 | 0.85 | MCHR1 (0.39) | HRH3KMT2AALDH1A1GAATDP1 | |
| SCHEMBL9602848 | 0.85 | HRH3 (0.40) | HRH3KMT2AALDH1A1GAA | |
| SCHEMBL9866493 | 0.82 | HRH3 (0.41) | HRH3KMT2AALDH1A1GAATDP1 | |
| SCHEMBL9601997 | 0.81 | HRH3 (0.39) | HRH3KMT2AALDH1A1GAA | |
| SCHEMBL9601550 | 0.80 | HRH3 (0.40) | HRH3KMT2AALDH1A1GAA | |
| SCHEMBL9602782 | 0.80 | HRH3 (0.42) | HRH3KMT2AALDH1A1GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |