Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9603133 | 0.77 | CYP11B1 (0.42) | MEN1KMT2APLCG1ALDH1A1GRM5 | |
| SCHEMBL1629546 | 0.76 | MEN1 (0.44) | MEN1KMT2AALDH1A1POLBGAA | |
| SCHEMBL18486629 | 0.72 | MEN1 (0.61) | MEN1KMT2AALDH1A1POLBLMNA | |
| SCHEMBL10221817 | 0.70 | PKM (0.49) | MEN1KMT2APLCG1ALDH1A1GRM5 | |
| SCHEMBL9224332 | 0.70 | MEN1 (0.42) | MEN1KMT2AALDH1A1POLBGAA | |
| SCHEMBL6109965 | 0.70 | CYP11B1 (0.53) | PLCG1ALDH1A1CYP11B1CYP1A2CYP3A4 | |
| SCHEMBL20182015 | 0.70 | KMT2A (0.42) | MEN1KMT2AALDH1A1POLBLMNA | |
| SCHEMBL17696213 | 0.68 | GRM5 (0.44) | PLCG1ALDH1A1GRM5LMNANEK2 | |
| SCHEMBL1631244 | 0.68 | CYP2D6 (0.42) | MEN1KMT2AALDH1A1 | |
| SCHEMBL22940440 | 0.68 | ALDH1A1 (0.36) | MEN1KMT2APLCG1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5217963-A | Antiischemic, antiepileptic agent | CIBA-GEIGY CORPORATION (US) | 1993-06-08 | — | — | US | disclosed |
| US-5057506-A | Anticonvulsants, antispasmodic and antischemic agents | CIBA-GEIGY CORPORATION (US) | 1991-10-15 | — | — | US | disclosed |
| US-4906621-A | Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade | CIBA-GEIGY CORPORATION (US) | 1990-03-06 | — | — | US | disclosed |
| US-4898854-A | NERVOUS SYSTEM DISORDERS | CIBA-GEIGY CORPORATION (US) | 1990-02-06 | — | — | US | disclosed |