Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 3/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 4/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.30 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.30 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9596470 | 0.90 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DBACE1 | |
| SCHEMBL9827460 | 0.87 | ABCC9 (0.40) | PDE4APDE4BPDE4CPDE4DPGR | |
| SCHEMBL7267642 | 0.83 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DBACE1 | |
| SCHEMBL7269375 | 0.82 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL8088661 | 0.81 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| Bimakalim SCHEMBL231904 | 0.81 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9299687 | 0.80 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9299240 | 0.79 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9300068 | 0.79 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9299270 | 0.78 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0413438-A1 | Benzopyran compounds | Beecham Group p.l.c. (GB) | 1991-02-20 | — | — | EP | claimed |
| US-5189047-A | Useful in the treament of respiratory track disorder, hypertension and bronchodilator activity or utility as potassium channel activator | BEECHAM GROUP P.L.C. (GB) | 1993-02-23 | — | — | US | disclosed |