Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATF4 | P18848 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9601493 | 0.89 | MAPT (0.40) | MAPTMEN1KMT2ALMNAKDM4E | |
| SCHEMBL10368047 | 0.84 | POLB (0.44) | MAPTMEN1KMT2ALMNANPC1 | |
| SCHEMBL10365420 | 0.83 | MAPT (0.41) | MAPTMEN1KMT2ALMNATDP1 | |
| SCHEMBL9601978 | 0.82 | MEN1 (0.35) | MAPTMEN1KMT2ALMNATDP1 | |
| SCHEMBL9601960 | 0.82 | CDK4 (0.34) | MCHR1 | |
| SCHEMBL10366190 | 0.82 | DRD2 (0.43) | MAPTMEN1KMT2ALMNATDP1 | |
| Fumaric Acid SCHEMBL9602985 | 0.81 | MAPT (0.33) | MAPTMEN1KMT2ALMNATDP1 | |
| Fumaric Acid SCHEMBL9602984 | 0.81 | MAPT (0.33) | MAPTMEN1KMT2ALMNATDP1 | |
| SCHEMBL10367909 | 0.81 | GRM5 (0.36) | MAPTMEN1KMT2ALMNATDP1 | |
| SCHEMBL10367469 | 0.81 | MAPT (0.38) | MAPTMEN1KMT2ALMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |