Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | PRKCZ | Q05513 | 8/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865057 | 0.91 | PBRM1 (0.39) | ALDH1A1MAPTKMT2AESR2PTGS2 | |
| SCHEMBL10367909 | 0.90 | GRM5 (0.36) | MEN1ALDH1A1LMNAMAPTHTT | |
| SCHEMBL10365420 | 0.90 | MAPT (0.41) | MEN1ALDH1A1LMNAMAPTHTT | |
| SCHEMBL10366230 | 0.89 | ALDH1A1 (0.37) | MEN1ALDH1A1LMNAMAPTHTT | |
| SCHEMBL7287680 | 0.89 | ALDH1A1 (0.43) | MEN1ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL10367579 | 0.88 | PRKCZ (0.41) | MEN1ALDH1A1LMNAMAPTHTT | |
| SCHEMBL9602844 | 0.88 | ACHE (0.35) | ALDH1A1MAPTESR2PRKCZPTGS2 | |
| SCHEMBL10660494 | 0.87 | KDM4E (0.34) | MEN1ALDH1A1MAPTKMT2AESR2 | |
| SCHEMBL9601954 | 0.87 | MAOB (0.40) | ALDH1A1LMNAMAPTKMT2APRKCZ | |
| SCHEMBL10368047 | 0.86 | POLB (0.44) | MEN1ALDH1A1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |