Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.33 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.31 |
| ▸ | S1PR1 known ✓ | P21453 | 2/20 | 0.30 |
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9602984 | 1.00 | MAPT (0.33) | MAPTLMNAALDH1A1MEN1KMT2A | |
| Fumaric Acid SCHEMBL9603164 | 0.91 | KDM4E (0.35) | MAPTLMNAALDH1A1GAAHTR2A | |
| Fumaric Acid SCHEMBL9603160 | 0.91 | KDM4E (0.35) | MAPTLMNAALDH1A1GAAHTR2A | |
| Maleic Acid SCHEMBL9866351 | 0.90 | ALDH1A1 (0.33) | LMNAALDH1A1L3MBTL1POLBTHRB | |
| Fumaric Acid SCHEMBL9866359 | 0.90 | ALDH1A1 (0.33) | LMNAALDH1A1L3MBTL1POLBTHRB | |
| SCHEMBL9601960 | 0.84 | CDK4 (0.34) | S1PR1S1PR3 | |
| SCHEMBL9602515 | 0.84 | ALDH1A1 (0.33) | MAPTLMNAALDH1A1GAAHTR2A | |
| SCHEMBL9867304 | 0.84 | MAOA (0.35) | MEN1KMT2AGAASMN1; SMN2HPGD | |
| SCHEMBL9603020 | 0.81 | MAPT (0.39) | MAPTLMNAMEN1KMT2ATDP1 | |
| Fumaric Acid SCHEMBL9865911 | 0.80 | KDM4E (0.35) | MAPTLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |