Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 20/20 | 0.72 |
| ▸ | CHUK | O15111 | 18/20 | 0.72 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | BTK | Q06187 | 2/20 | 0.56 |
| ▸ | ITK | Q08881 | 2/20 | 0.56 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5083193 | 0.84 | IKBKB (1.00) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL22145812 | 0.84 | IKBKB (0.56) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL26627901 | 0.84 | IKBKB (0.52) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL13533464 | 0.81 | IKBKB (0.67) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL13533465 | 0.81 | IKBKB (0.50) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL13533460 | 0.80 | IKBKB (0.49) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL9601077 | 0.80 | IKBKB (0.58) | IKBKBCHUK | |
| SCHEMBL13533461 | 0.79 | YTHDC1 (0.60) | IKBKBCHUK | |
| SCHEMBL14537693 | 0.79 | IKBKB (0.48) | IKBKBCHUKCDK2BTKITK | |
| SCHEMBL9601821 | 0.78 | IKBKB (0.46) | IKBKBCHUKCDK2BTKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567329-B2 | High penetration prodrug compositions of 1H-imidazo[4,5-c]quinolin-4-amines and 1H-imidazo[4,5-c]quinolin-4-amine-related compounds and uses thereof | TECHFIELDS PHARMA CO., LTD. (CN) | 2017-02-14 | — | — | US | disclosed |
| US-9567329-B2 | High penetration prodrug compositions of 1H-imidazo[4,5-c]quinolin-4-amines and 1H-imidazo[4,5-c]quinolin-4-amine-related compounds and uses thereof | TECHFIELDS PHARMA CO., LTD. (CN) | 2017-02-14 | — | — | US | disclosed |
| US-20130131100-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS AND USES THEREOF | PREMIER RESEARCH INTERNATIONAL, LLC | 2013-05-23 | — | — | US | disclosed |
| US-20130131100-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS AND USES THEREOF | PREMIER RESEARCH INTERNATIONAL, LLC | 2013-05-23 | — | — | US | disclosed |
| US-8349866-B2 | High penetration prodrug compositions of 1H-imidazo[4,5-C]quinolin-4-amines and 1H-imidazo[4,5-C]quinolin-4-amine-related compounds | PREMIER RESEARCH INTERNATIONAL, LLC | 2013-01-08 | — | — | US | disclosed |
| US-8349866-B2 | High penetration prodrug compositions of 1H-imidazo[4,5-C]quinolin-4-amines and 1H-imidazo[4,5-C]quinolin-4-amine-related compounds | PREMIER RESEARCH INTERNATIONAL, LLC | 2013-01-08 | — | — | US | disclosed |
| US-20100021394-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS | PREMIER RESEARCH INTERNATIONAL, LLC | 2010-01-28 | — | — | US | disclosed |
| EP-0310950-B1 | Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes | RIKER LABORATORIES, INC. (US) | 1993-01-13 | — | — | EP | disclosed |
| EP-0145340-B1 | 1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines | RIKER LABORATORIES, INC. (US) | 1990-01-24 | — | — | EP | disclosed |
| EP-0310950-A1 | Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes | RIKER LABORATORIES, INC. (US) | 1989-04-12 | — | — | EP | disclosed |
| US-4698348-A | 1H-imidazo[4,5-c]quinolines and their use as bronchodilating agents | RIKER LABORATORIES, INC. (US) | 1987-10-06 | — | — | US | disclosed |
| EP-0145340-A2 | 1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines | RIKER LABORATORIES, INC. (US) | 1985-06-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131100-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS AND USES THEREOF | HRH4, SLC7A1, ABCG2 | IKBKB 3526/4885CHUK 1647/4885CDK2 745/4885 |
| US-20100021394-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS | SLC7A1, HRH4, CYP3A4 | IKBKB 3574/4885CHUK 1733/4885CDK2 838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.