Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9604869 | 0.73 | CA2 (0.42) | CA9CA12CA1CA2CA4 | |
| SCHEMBL20777728 | 0.64 | CA2 (0.36) | CA9CA12CA1CA2CA4 | |
| SCHEMBL11677692 | 0.61 | CA12 (0.54) | CA9CA12CA1CA2CA4 | |
| SCHEMBL7773292 | 0.59 | TTR (0.42) | CA9CA12CA1CA2CA4 | |
| SCHEMBL21870 | 0.57 | KDM4E (0.55) | KDM4ETPMT | |
| SCHEMBL377596 | 0.57 | KDM4E (0.55) | KDM4ETPMT | |
| SCHEMBL17558193 | 0.56 | KDM4E (0.53) | KDM4ETPMT | |
| SCHEMBL6912557 | 0.56 | KDM4E (0.53) | KDM4ETPMT | |
| SCHEMBL6917032 | 0.56 | KDM4E (0.53) | KDM4ETPMT | |
| SCHEMBL6915449 | 0.56 | KDM4E (0.53) | KDM4ETPMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993021171-A1 | USE OF 2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES FOR PREPARING NMDA/AMPA RECEPTOR ANTAGONIST DRUGS, NOVEL PRODUCTS, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1993-10-28 | — | — | WO | disclosed |