Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2297450 | 0.86 | KMT2A (0.44) | KMT2AKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL1974562 | 0.86 | DHODH (0.44) | KMT2AKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL12002016 | 0.82 | ALDH1A1 (0.43) | KMT2AKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL3564311 | 0.79 | PTGER4 (0.40) | KMT2AKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL3557535 | 0.77 | ALOX5 (0.45) | KMT2AKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL3571297 | 0.77 | KMT2A (0.39) | KMT2AKDM4EALDH1A1LMNAPTGER4 | |
| SCHEMBL1590125 | 0.77 | EDNRA (0.52) | KMT2AKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL6931142 | 0.76 | EDNRA (0.40) | DHODHPTGER4EDNRACNR1CNR2 | |
| SCHEMBL3570038 | 0.76 | EDNRA (0.40) | DHODHPTGER4EDNRACNR1CNR2 | |
| SCHEMBL27745290 | 0.75 | DHODH (0.42) | KMT2AKDM4EALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457897-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2012-05-30 | — | — | EP | disclosed |