Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9372680 | 0.83 | ALDH1A1 (0.41) | POLBL3MBTL1ALDH1A1RAB9ANPC1 | |
| SCHEMBL18176042 | 0.81 | FBP1 (0.43) | POLBL3MBTL1ALDH1A1CDC7DBF4 | |
| SCHEMBL12853061 | 0.78 | POLB (0.44) | POLBL3MBTL1ALDH1A1RAB9ANPC1 | |
| SCHEMBL10272061 | 0.77 | ALDH1A1 (0.53) | POLBL3MBTL1ALDH1A1HTR2CRAB9A | |
| SCHEMBL9607352 | 0.75 | ALDH1A1 (0.41) | L3MBTL1ALDH1A1CDC7DBF4RAB9A | |
| SCHEMBL7233421 | 0.72 | NPC1 (0.54) | ALDH1A1CDC7DBF4RAB9ANPC1 | |
| SCHEMBL10220111 | 0.71 | POLB (0.51) | POLBL3MBTL1ALDH1A1HTR2CRAB9A | |
| SCHEMBL16479899 | 0.71 | NPC1 (0.43) | L3MBTL1ALDH1A1RAB9ANPC1TP53 | |
| SCHEMBL4527669 | 0.69 | ALDH1A1 (0.39) | POLBL3MBTL1ALDH1A1RAB9ANPC1 | |
| SCHEMBL10431205 | 0.68 | CTSL (0.40) | L3MBTL1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012071519-A1 | BENZOXAZEPINES AS INHIBITORS OF P13K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-31 | — | — | WO | disclosed |