SCHEMBL9607710

SCHEMBL9607710

C#CCc1cccc(-c2cccc(-c3ncc4ccccc4n3)n2)c1

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.41
MAOB P27338 5/20 0.36
HRH3 Q9Y5N1 1/20 0.35
MAOA P21397 2/20 0.34
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
CDK8 P49336 2/20 0.32
MAP4K4 O95819 1/20 0.32
CSNK1G2 P78368 1/20 0.32
CLK4 Q9HAZ1 1/20 0.32
MKNK2 Q9HBH9 1/20 0.32
MAP4K5 Q9Y4K4 1/20 0.32
IDO1 P14902 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8776113 0.88 MMP3 (0.41) CYP1A2HRH3MEN1KMT2A
SCHEMBL8775836 0.84 FYN (0.43) CYP1A2CDK8
SCHEMBL3784385 0.78 RAB9A (0.55) CYP1A2NPC1RAB9AMEN1KMT2A
SCHEMBL8775191 0.77 BCHE (0.48) CYP1A2RAB9AMEN1KMT2AIDO1
SCHEMBL8775671 0.77 HSD17B1 (0.50) CYP1A2RAB9AMAP4K4
SCHEMBL8775105 0.77 BCHE (0.48) CYP1A2MEN1KMT2AMAP4K4IDO1
SCHEMBL8776094 0.76 CYP1A2 (0.47) CYP1A2NPC1RAB9AMEN1KMT2A
SCHEMBL8775301 0.74 TP53 (0.46) CYP1A2NPC1RAB9AMEN1KMT2A
SCHEMBL8775690 0.73 CYP1A2 (0.43) CYP1A2NPC1RAB9AMEN1KMT2A
SCHEMBL8775416 0.73 CYP1A2 (0.50) CYP1A2NPC1RAB9AMAP4K4CLK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012069652-A2 FUNGICIDE MIXTURES SYNGENTA PARTICIPATIONS AG (CH) 2012-05-31 WO disclosed