Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | GPR52 | Q9Y2T5 | 13/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.48 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.43 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9608613 | 0.92 | MAPT (0.56) | MAPTGPR52HCAR2AKR1B10AKR1B1 | |
| SCHEMBL1268421 | 0.89 | MAPT (0.62) | MAPTGPR52HCAR2 | |
| SCHEMBL1268422 | 0.89 | MAPT (0.62) | MAPTGPR52HCAR2 | |
| SCHEMBL31682746 | 0.89 | MAPT (0.53) | MAPTHCAR2AKR1B10AKR1B1 | |
| SCHEMBL10453292 | 0.87 | MAPT (0.45) | MAPTGPR52HCAR2AKR1B10AKR1B1 | |
| SCHEMBL27311627 | 0.87 | MAPT (0.59) | MAPTGPR52HCAR2 | |
| SCHEMBL27310629 | 0.87 | MAPT (0.59) | MAPTGPR52HCAR2 | |
| SCHEMBL27311625 | 0.87 | MAPT (0.59) | MAPTGPR52HCAR2 | |
| SCHEMBL27310628 | 0.87 | MAPT (0.59) | MAPTGPR52HCAR2 | |
| SCHEMBL10593997 | 0.85 | MAPT (0.52) | MAPTHCAR2LMNAMDM2MDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852581-B1 | NOVEL 1,3-BENZOXAZOL-2(3H)-ONES AND THEIR USE AS MEDICAMENTS AND COSMETICS | WOLFF AUGUST GMBH & CO KG ARZNEIMITTEL DR (DE) | 2016-05-04 | — | — | EP | disclosed |
| US-9199948-B2 | 1,3-benzoxazol-2(3H)-ones and their use as medicaments and cosmetics | DR. AUGUST WOLFF GMBH & CO. KG ARZNEIMITTEL (DE) | 2015-12-01 | — | — | US | disclosed |
| US-9199948-B2 | 1,3-benzoxazol-2(3H)-ones and their use as medicaments and cosmetics | DR. AUGUST WOLFF GMBH & CO. KG ARZNEIMITTEL (DE) | 2015-12-01 | — | — | US | disclosed |
| US-20150111935-A1 | NOVEL 1,3-BENZOXAZOL-2(3H)-ONES AND THEIR USE AS MEDICAMENTS AND COSMETICS | DR. AUGUST WOLFF GMBH & CO. KG ARZNEIMITTEL (DE) | 2015-04-23 | — | — | US | disclosed |
| US-20150111935-A1 | NOVEL 1,3-BENZOXAZOL-2(3H)-ONES AND THEIR USE AS MEDICAMENTS AND COSMETICS | DR. AUGUST WOLFF GMBH & CO. KG ARZNEIMITTEL (DE) | 2015-04-23 | — | — | US | disclosed |
| WO-2012069605-A1 | NOVEL E,E-DIENE COMPOUNDS AND THEIR USE AS MEDICAMENTS AND COSMETICS | DR. AUGUST WOLFF GMBH & CO. KG ARZNEIMITTEL (DE) | 2012-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111935-A1 | NOVEL 1,3-BENZOXAZOL-2(3H)-ONES AND THEIR USE AS MEDICAMENTS AND COSMETICS | TRPV1, TRPA1, P2RX3 | MAPT 3950/4885GPR52 460/4885HCAR2 144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.