Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | PDE5A | O76074 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8485494 | 0.88 | RPS6KB1 (0.47) | RPS6KB1AURKAAPPMAPK1HTR1A | |
| SCHEMBL8491743 | 0.87 | RPS6KB1 (0.46) | RPS6KB1AURKAAPPMAPK1EGFR | |
| SCHEMBL8504575 | 0.87 | RPS6KB1 (0.46) | RPS6KB1AURKAAPPMAPK1EGFR | |
| SCHEMBL8490466 | 0.85 | RPS6KB1 (0.49) | RPS6KB1AURKAAPPMAPK1EGFR | |
| SCHEMBL8498027 | 0.82 | AURKA (0.47) | RPS6KB1AURKAPDE5AAPPMAPK1 | |
| SCHEMBL8484236 | 0.80 | LDHA (0.46) | APPMAPK1EGFRLDHASMN1; SMN2 | |
| SCHEMBL8484113 | 0.79 | HTT (0.42) | PDE5AAPPMAPK1EGFRLDHA | |
| SCHEMBL8516979 | 0.78 | KMT2A (0.41) | PDE5AAPPMAPK1LDHASMN1; SMN2 | |
| SCHEMBL8483285 | 0.78 | APP (0.68) | APPMAPK1EGFRLDHASMN1; SMN2 | |
| SCHEMBL8483456 | 0.77 | RXFP1 (0.42) | PDE5AAPPMAPK1LDHASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120136150-A1 | 4-(3-Butynyl)Aminopyrimidine Derivatives as Pest Control Agents for Agricultural and Horticultural Use | SDS BIOTECH K.K. (JP) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136150-A1 | 4-(3-Butynyl)Aminopyrimidine Derivatives as Pest Control Agents for Agricultural and Horticultural Use | CBR3, CBR1, HRH2 | RPS6KB1 3088/4885AURKA 3468/4885PDE5A 4002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.