Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CASP6 | P55212 | 1/20 | 0.57 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 7/20 | 0.51 |
| ▸ | HTR2C | P28335 | 7/20 | 0.51 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404339 | 0.90 | SIRT1 (0.55) | SIRT1RECQLSIRT2GAACASP6 | |
| SCHEMBL25784905 | 0.89 | HTR2A (0.66) | SIRT1SIRT2HTR2AHTR2CLMNA | |
| SCHEMBL15101410 | 0.82 | SIRT1 (0.65) | SIRT1RECQLSIRT2GAACASP6 | |
| SCHEMBL12325749 | 0.81 | SIRT1 (0.67) | SIRT1RECQLSIRT2GAACASP6 | |
| SCHEMBL4027054 | 0.81 | SIRT1 (0.66) | SIRT1RECQLSIRT2GAACASP6 | |
| SCHEMBL18648563 | 0.81 | BRD3 (0.52) | SIRT1SIRT2LMNA | |
| SCHEMBL16941536 | 0.79 | GAA (0.65) | SIRT1RECQLSIRT2GAACASP6 | |
| SCHEMBL28372988 | 0.78 | SIRT1 (0.63) | SIRT1RECQLSIRT2GAACASP6 | |
| SCHEMBL3676864 | 0.78 | SIRT1 (0.62) | SIRT1RECQLSIRT2GAACASP6 | |
| SCHEMBL1872225 | 0.77 | SIRT1 (1.00) | SIRT1RECQLSIRT2GAACASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120136154-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES | PTC THERAPEUTICS, INC. | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136154-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES | TPH1, TPH2, HTR1B | SIRT1 1531/4885RECQL 1357/4885SIRT2 988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.