Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 10/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1201779 | 0.79 | POLB (0.38) | HPGDSPTGESLMNAMEN1KMT2A | |
| SCHEMBL8259922 | 0.77 | HPGDS (0.40) | HPGDSKMT2APOLBSMN1; SMN2HDAC3 | |
| SCHEMBL1201671 | 0.70 | HPGDS (0.42) | HPGDSPTGESLMNAMEN1KMT2A | |
| SCHEMBL4241471 | 0.69 | PTGES (0.41) | HPGDSPTGESLMNAMEN1KMT2A | |
| SCHEMBL9611625 | 0.68 | RAB9A (0.34) | HPGDSPTGESMEN1KMT2AHTT | |
| SCHEMBL1202444 | 0.68 | GAA (0.40) | LMNAMEN1KMT2APOLBHTT | |
| SCHEMBL1201611 | 0.68 | HPGDS (0.37) | HPGDSPTGESLMNAMEN1KMT2A | |
| SCHEMBL4241467 | 0.68 | PTGES (0.39) | HPGDSPTGESLMNAMEN1KMT2A | |
| SCHEMBL1201781 | 0.67 | MEN1 (0.39) | LMNAMEN1KMT2APOLBHTT | |
| SCHEMBL1202299 | 0.66 | HPGDS (0.41) | HPGDSPTGESLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457901-A1 | Benzazole derivatives, compositions, and methods of use as B-secretase inhibitors | High Point Pharmaceuticals, LLC (US) | 2012-05-30 | — | — | EP | disclosed |