Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.67 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.67 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.67 |
| ▸ | PPIA | P62937 | 1/20 | 0.67 |
| ▸ | PPID | Q08752 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.67 |
| ▸ | HPGD | P15428 | 9/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | KLK7 | P49862 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | PTPN7 | P35236 | 5/20 | 0.66 |
| ▸ | CASP1 | P29466 | 5/20 | 0.66 |
| ▸ | CASP7 | P55210 | 4/20 | 0.66 |
| ▸ | THRB | P10828 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9613313 | 0.81 | KDM4E (0.97) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL9613308 | 0.81 | TDP1 (1.00) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL9613331 | 0.80 | KDM4E (1.00) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL13856682 | 0.80 | PTPN7 (1.00) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL19174170 | 0.78 | KDM4E (0.56) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL19174171 | 0.78 | ALDH1A1 (0.67) | KDM4EHPGDALDH1A1RAB9AHSD17B10 | |
| SCHEMBL9613310 | 0.78 | KDM4E (0.74) | TDP1KDM4EHPGDALDH1A1RAB9A | |
| SCHEMBL9613322 | 0.78 | PTPN7 (0.67) | KDM4EHPGDALDH1A1RAB9AGAA | |
| SCHEMBL20467485 | 0.77 | HPGD (0.97) | KDM4EHPGDALDH1A1RAB9AGAA | |
| SCHEMBL25009255 | 0.77 | NPC1 (0.55) | RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353094-B2 | Substituted quinoxalines as kinase inhibitors | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2016-05-31 | — | — | US | disclosed |
| US-20150274709-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM | 2015-10-01 | — | — | US | disclosed |
| US-8993758-B2 | Substituted quinoxalines and uses thereof | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2015-03-31 | — | — | US | disclosed |
| US-20130289041-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2013-10-31 | — | — | US | disclosed |
| WO-2012071414-A2 | QUINOXALINE COMPOUNDS AND USES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2012-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274709-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | NFKBIA, RELA, MTOR | TDP1 3381/4885HSPD1 1050/4885HSPE1 762/4885 |
| US-20130289041-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | NFKBIA, RELA, MTOR | TDP1 3381/4885HSPD1 1050/4885HSPE1 762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.