Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | PPIA | P62937 | 2/20 | 1.00 |
| ▸ | PPID | Q08752 | 2/20 | 1.00 |
| ▸ | HSPD1 | P10809 | 2/20 | 1.00 |
| ▸ | HSPE1 | P61604 | 2/20 | 1.00 |
| ▸ | PTPN7 | P35236 | 9/20 | 0.98 |
| ▸ | MEN1 | O00255 | 3/20 | 0.98 |
| ▸ | POLB | P06746 | 3/20 | 0.98 |
| ▸ | HPGD | P15428 | 3/20 | 0.98 |
| ▸ | BLM | P54132 | 3/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.98 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.98 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | MAPT | P10636 | 2/20 | 0.98 |
| ▸ | THRB | P10828 | 2/20 | 0.98 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.98 |
| ▸ | CASP1 | P29466 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13856682 | 0.99 | PTPN7 (1.00) | TDP1PPIAPPIDHSPD1HSPE1 | |
| SCHEMBL9613368 | 0.91 | PTPN7 (1.00) | TDP1PPIAPPIDHSPD1HSPE1 | |
| SCHEMBL5997551 | 0.86 | KDM4D (0.98) | TDP1PPIAPPIDHSPD1HSPE1 | |
| SCHEMBL5992705 | 0.85 | KDM4D (1.00) | TDP1PPIAPPIDHSPD1HSPE1 | |
| SCHEMBL9613352 | 0.83 | PTPN7 (0.73) | TDP1PPIAPPIDHSPD1HSPE1 | |
| SCHEMBL2116513 | 0.81 | PTPN7 (1.00) | TDP1PPIAPPIDHSPD1HSPE1 | |
| SCHEMBL9613309 | 0.81 | TDP1 (0.67) | TDP1PPIAPPIDHSPD1HSPE1 | |
| SCHEMBL9613359 | 0.80 | PTPN7 (0.77) | TDP1PPIAPPIDHSPD1HSPE1 | |
| SCHEMBL6238251 | 0.78 | PTPN7 (1.00) | TDP1PPIAPPIDHSPD1HSPE1 | |
| SCHEMBL9613399 | 0.77 | TDP1 (0.62) | TDP1PPIAPPIDHSPD1HSPE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10179161-B2 | Compositions and methods for enhancing cardiac function in the neonate | THE UNIVERSITY OF ROCHESTER (US) | 2019-01-15 | — | — | US | claimed |
| US-10179161-B2 | Compositions and methods for enhancing cardiac function in the neonate | THE UNIVERSITY OF ROCHESTER (US) | 2019-01-15 | — | — | US | disclosed |
| US-9833467-B2 | Use of cyclophilin D inhibitors to treat or prevent bone disorders | UNIVERSITY OF ROCHESTER (US) | 2017-12-05 | — | — | US | disclosed |
| US-20170239322-A1 | COMPOSITIONS AND METHODS FOR ENHANCING CARDIAC FUNCTION IN THE NEONATE | UNIV ROCHESTER (US) | 2017-08-24 | — | — | US | disclosed |
| US-9353094-B2 | Substituted quinoxalines as kinase inhibitors | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2016-05-31 | — | — | US | disclosed |
| US-20150320828-A1 | USE OF CYCLOPHILIN D INHIBITORS TO TREAT OR PREVENT BONE DISORDERS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2015-11-12 | — | — | US | disclosed |
| US-20150274709-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM | 2015-10-01 | — | — | US | disclosed |
| US-8993758-B2 | Substituted quinoxalines and uses thereof | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140050728-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CYCLOPHILIN D FOR THE TREATMENT AND PREVENTION OF OBESITY AND KIDNEY INDICATIONS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2014-02-20 | — | — | US | disclosed |
| US-20130289041-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2013-10-31 | — | — | US | disclosed |
| WO-2012071414-A2 | QUINOXALINE COMPOUNDS AND USES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2012-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10179161-B2 | Compositions and methods for enhancing cardiac function in the neonate | TNNI3, TNNT2, TNNC1 | TDP1 3476/4885PPIA 1998/4885PPID 2040/4885 |
| US-20170239322-A1 | COMPOSITIONS AND METHODS FOR ENHANCING CARDIAC FUNCTION IN THE NEONATE | TNNI3, TNNT2, TNNC1 | TDP1 3476/4885PPIA 1998/4885PPID 2040/4885 |
| US-20150274709-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | NFKBIA, RELA, MTOR | TDP1 3381/4885PPIA 1747/4885PPID 2029/4885 |
| US-20140050728-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CYCLOPHILIN D FOR THE TREATMENT AND PREVENTION OF OBESITY AND KIDNEY INDICATIONS | PPIG, FKBP1B, PPIH | TDP1 4191/4885PPIA 27/4885PPID 8/4885 |
| US-20130289041-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | NFKBIA, RELA, MTOR | TDP1 3381/4885PPIA 1747/4885PPID 2029/4885 |
| US-20150320828-A1 | USE OF CYCLOPHILIN D INHIBITORS TO TREAT OR PREVENT BONE DISORDERS | PPID, PPIH, FKBP1A | TDP1 1319/4885PPIA 22/4885PPID 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.