Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC13A5 | Q86YT5 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL10484280 | 0.88 | SLC13A5 (0.39) | SLC13A5KDM4ELMNACYP2D6CYP2C19 | |
| SCHEMBL9613754 | 0.79 | SLC13A5 (0.40) | SLC13A5KDM4ELMNAPDE10AADRB2 | |
| SCHEMBL9291814 | 0.76 | PPARG (0.41) | CYP2D6ADRB2MCL1 | |
| SCHEMBL10484293 | 0.71 | SLC13A5 (0.39) | SLC13A5KDM4ELMNACYP2D6PDE10A | |
| Citric Acid SCHEMBL3986 | 0.70 | SLC6A4 (0.43) | SLC13A5CYP2D6CYP2C19 | |
| SCHEMBL14613949 | 0.67 | NCEH1 (0.42) | ALDH1A1 | |
| Oxalic Acid SCHEMBL9614060 | 0.65 | KMT2A (0.62) | KDM4EALDH1A1MCL1 | |
| Citric Acid SCHEMBL9520797 | 0.65 | SLC13A5 (0.55) | SLC13A5KDM4ELMNACYP2D6 | |
| Citric Acid SCHEMBL9613830 | 0.65 | SLC13A5 (0.42) | SLC13A5KDM4ELMNACYP2D6CYP2C19 | |
| Citric Acid SCHEMBL28294783 | 0.64 | LMNA (0.67) | SLC13A5KDM4ELMNACYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135947-A | Treatment of depression, eating disorders, and alcoholism | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0288188-B1 | 1-PHENYL-3-NAPHTHALENYLOXY-PROPANAMINES | ELI LILLY AND COMPANY (US) | 1991-10-16 | — | — | EP | disclosed |