Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 4/20 | 0.33 |
| ▸ | CNR2 | P34972 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9613887 | 0.93 | CNR2 (0.34) | ALDH1A1PPARASMN1; SMN2TTRCYP1A2 | |
| SCHEMBL10484357 | 0.82 | SIRT1 (0.32) | ALDH1A1SMN1; SMN2CYP1A2KDM4EHPGD | |
| SCHEMBL9614062 | 0.78 | ALDH1A1 (0.50) | ALDH1A1TDP1KDM4EHPGDKMT2A | |
| SCHEMBL9613821 | 0.74 | CNR2 (0.35) | ALDH1A1PPARASMN1; SMN2TTRCYP1A2 | |
| SCHEMBL9613818 | 0.73 | KDM4E (0.38) | ALDH1A1PPARASMN1; SMN2TTRCYP1A2 | |
| SCHEMBL9613732 | 0.68 | KDM4E (0.46) | ALDH1A1TDP1KDM4EHPGDKMT2A | |
| Oxalic Acid SCHEMBL9613781 | 0.67 | HTR1D (0.41) | ALDH1A1SMN1; SMN2TDP1KDM4EMEN1 | |
| SCHEMBL9613816 | 0.67 | HTR1B (0.46) | ALDH1A1TSHRTDP1KDM4EHPGD | |
| SCHEMBL14396287 | 0.66 | IDO1 (0.66) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9KDM4E | |
| SCHEMBL9613918 | 0.66 | CYP2D6 (0.40) | ALDH1A1SMN1; SMN2TDP1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135947-A | Treatment of depression, eating disorders, and alcoholism | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0288188-B1 | 1-PHENYL-3-NAPHTHALENYLOXY-PROPANAMINES | ELI LILLY AND COMPANY (US) | 1991-10-16 | — | — | EP | disclosed |
| EP-0288188-A1 | 1-Phenyl-3-naphthalenyloxy-propanamines | ELI LILLY AND COMPANY (US) | 1988-10-26 | — | — | EP | disclosed |