Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HTR1B | P28222 | 8/20 | 0.49 |
| ▸ | HTR1D | P28221 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | OGG1 | O15527 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | BAD | Q92934 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9613732 | 0.89 | KDM4E (0.46) | ALDH1A1KDM4EHPGDHTR1BHTR1D | |
| SCHEMBL9613887 | 0.85 | CNR2 (0.34) | ALDH1A1KDM4EHPGDTDP1KMT2A | |
| SCHEMBL9613721 | 0.84 | HTR1B (0.47) | ALDH1A1KDM4EHPGDHTR1BHTR1D | |
| SCHEMBL9613811 | 0.79 | KDM4E (0.50) | ALDH1A1KDM4EHPGDHTR1BHTR1D | |
| SCHEMBL9614076 | 0.79 | HTR1B (0.49) | ALDH1A1KDM4EHPGDHTR1BHTR1D | |
| SCHEMBL10484353 | 0.79 | MTNR1A (0.45) | ALDH1A1KDM4ETDP1KMT2AMCL1 | |
| SCHEMBL9613786 | 0.78 | ALDH1A1 (0.34) | ALDH1A1KDM4EHPGDTDP1KMT2A | |
| SCHEMBL29289438 | 0.77 | HTR1B (0.56) | ALDH1A1KDM4EHPGDHTR1BHTR1D | |
| Hydrochloric Acid SCHEMBL29289439 | 0.76 | HTR1B (0.55) | ALDH1A1KDM4EHPGDHTR1BHTR1D | |
| SCHEMBL9613717 | 0.74 | MCL1 (0.45) | ALDH1A1KDM4EHPGDHTR1BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135947-A | Treatment of depression, eating disorders, and alcoholism | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0288188-B1 | 1-PHENYL-3-NAPHTHALENYLOXY-PROPANAMINES | ELI LILLY AND COMPANY (US) | 1991-10-16 | — | — | EP | disclosed |