SCHEMBL9615418

SCHEMBL9615418

C=CCOC(=O)c1c[nH]c2ccccc2c1=O

nearest known ligand 0.69

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.56
CFTR P13569 3/20 0.52
GABRA1 P14867 4/20 0.50
GABRB2 P47870 4/20 0.50
ALDH1A1 P00352 1/20 0.50
TSHR P16473 1/20 0.50
HSD17B10 Q99714 1/20 0.50
NR4A2 P43354 2/20 0.49
GABRB1 P18505 2/20 0.48
GABRA3 P34903 2/20 0.48
HTR3E A5X5Y0 1/20 0.48
HTR3B O95264 1/20 0.48
HTR3A P46098 1/20 0.48
HTR3D Q70Z44 1/20 0.48
HTR3C Q8WXA8 1/20 0.48
CREBBP Q92793 1/20 0.48
PBRM1 Q86U86 1/20 0.48
CLEC4M Q9H2X3 1/20 0.47
GPR84 Q9NQS5 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3265121 0.90 CYP3A4 (0.61) CYP3A4ALDH1A1TSHRHSD17B10NR4A2
SCHEMBL30388638 0.90 CYP3A4 (0.61) CYP3A4ALDH1A1TSHRHSD17B10NR4A2
SCHEMBL376662 0.82 GABRA1 (0.69) CYP3A4CFTRGABRA1GABRB2ALDH1A1
SCHEMBL29475801 0.82 GABRA1 (0.69) CYP3A4CFTRGABRA1GABRB2ALDH1A1
Hydrochloric Acid SCHEMBL29008098 0.81 GABRA1 (0.67) CYP3A4CFTRGABRA1GABRB2ALDH1A1
Hydrochloric Acid SCHEMBL30417898 0.81 GABRA1 (0.67) CYP3A4CFTRGABRA1GABRB2ALDH1A1
SCHEMBL22704179 0.80 GABRA1 (0.61) CFTRGABRA1GABRB2ALDH1A1HSD17B10
SCHEMBL9831231 0.79 GABRA1 (0.49) CYP3A4GABRA1GABRB2ALDH1A1HSD17B10
SCHEMBL10662699 0.78 ROCK2 (0.44) CYP3A4GABRA1GABRB2GABRB1GABRA3
SCHEMBL27470560 0.77 GPR84 (0.43) CFTRGABRA1GABRB2ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4134055-A None JP disclosed
JP-H04134055-A DIALKYLAMINOACRYLIC ACID ALLYL ESTER AND PRODUCTION THEREOF UBE IND LTD 1992-05-07 JP disclosed