Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL9615895 | 0.91 | TDP1 (0.40) | TDP1GPR84USP2SMN1; SMN2MEN1 | |
| Fumaric Acid SCHEMBL9719242 | 0.86 | TDP1 (0.44) | TDP1USP2CYP1A2CYP3A4CYP2C19 | |
| Malic Acid SCHEMBL2952799 | 0.85 | TDP1 (0.59) | TDP1USP2HSD17B10SMN1; SMN2 | |
| Malic Acid SCHEMBL2963342 | 0.83 | TDP1 (0.60) | TDP1USP2HSD17B10SMN1; SMN2 | |
| Malic Acid SCHEMBL2959967 | 0.83 | TDP1 (0.51) | TDP1USP2HSD17B10SMN1; SMN2 | |
| Malic Acid SCHEMBL9615894 | 0.81 | GPR84 (0.38) | GPR84USP2CYP1A2CYP3A4CYP2C19 | |
| Malic Acid SCHEMBL2953325 | 0.78 | TDP1 (0.43) | TDP1SMN1; SMN2 | |
| Malic Acid SCHEMBL2956745 | 0.76 | TDP1 (0.44) | TDP1SMN1; SMN2 | |
| Malic Acid SCHEMBL2958837 | 0.76 | SMN1; SMN2 (0.44) | TDP1HSD17B10SMN1; SMN2 | |
| Malic Acid SCHEMBL2960000 | 0.76 | SMN1; SMN2 (0.44) | TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4175253-A | — | — | None | — | — | JP | disclosed |
| JP-H04175253-A | AGENT FOR PREVENTING LOWERING OF FLUIDITY OF CEMENT COMPOSITION | N M B:KK | 1992-06-23 | — | — | JP | disclosed |