Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL9615896 | 0.91 | TDP1 (0.41) | TDP1MEN1THRBHTTKMT2A | |
| Malic Acid SCHEMBL2959967 | 0.85 | TDP1 (0.51) | TDP1SMN1; SMN2USP2 | |
| Maleic Acid SCHEMBL9719240 | 0.85 | TDP1 (0.42) | TDP1TSHRMEN1THRBHTT | |
| Malic Acid SCHEMBL2952799 | 0.84 | TDP1 (0.59) | TDP1SMN1; SMN2USP2 | |
| SCHEMBL1393746 | 0.84 | TSHR (0.55) | TDP1TSHRMEN1THRBHTT | |
| Di(Hydroxyethyl)Ether SCHEMBL5694621 | 0.84 | TSHR (0.55) | TDP1TSHRMEN1THRBHTT | |
| Malic Acid SCHEMBL8977105 | 0.84 | TSHR (0.55) | TSHRMEN1THRBHTTKMT2A | |
| Malic Acid SCHEMBL2963342 | 0.83 | TDP1 (0.60) | TDP1SMN1; SMN2USP2 | |
| Butoxyethanol SCHEMBL491444 | 0.83 | TSHR (0.57) | TDP1TSHRMEN1THRBHTT | |
| SCHEMBL3733695 | 0.82 | TDP1 (0.41) | TDP1MAPTUSP2GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4175253-A | — | — | None | — | — | JP | disclosed |
| JP-H04175253-A | AGENT FOR PREVENTING LOWERING OF FLUIDITY OF CEMENT COMPOSITION | N M B:KK | 1992-06-23 | — | — | JP | disclosed |