Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | HTR6 | P50406 | 3/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | PKLR | P30613 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.57 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.56 |
| ▸ | GHSR | Q92847 | 1/20 | 0.56 |
| ▸ | PLAU | P00749 | 2/20 | 0.56 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9465080 | 0.84 | KMT2A (0.70) | KMT2AMEN1HTR6POLBSMN1; SMN2 | |
| SCHEMBL28396503 | 0.84 | PGR (0.77) | KMT2AMEN1SMN1; SMN2LMNAPKM | |
| SCHEMBL20021987 | 0.84 | PGR (0.77) | KMT2AMEN1SMN1; SMN2LMNAPKM | |
| SCHEMBL29549847 | 0.84 | PGR (0.77) | KMT2AMEN1SMN1; SMN2LMNAPKM | |
| SCHEMBL28271796 | 0.84 | HTR6 (0.83) | KMT2AHTR6POLBSMN1; SMN2LMNA | |
| SCHEMBL28271812 | 0.82 | HTR6 (1.00) | KMT2AHTR6POLBPKMHTT | |
| SCHEMBL2723618 | 0.82 | HTR6 (1.00) | KMT2AMEN1HTR6POLBSMN1; SMN2 | |
| SCHEMBL3258120 | 0.82 | KMT2A (0.68) | KMT2AMEN1HTR6SMN1; SMN2LMNA | |
| SCHEMBL28511975 | 0.81 | HTR6 (0.73) | KMT2AMEN1HTR6POLBPKM | |
| Hydrochloric Acid SCHEMBL18953392 | 0.81 | HTR6 (0.97) | KMT2AMEN1HTR6POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462179-A4 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | — | 1992-03-18 | — | — | EP | claimed |
| EP-0462179-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-27 | — | — | EP | claimed |
| WO-1990009787-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-09-07 | — | — | WO | claimed |