SCHEMBL9617482

SCHEMBL9617482

CS(=O)(=O)O.c1ccc(-c2nc3ccccc3o2)c(-c2nc3ccccc3o2)c1

nearest known ligand 0.69

Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 3/20 0.69
TOP2A P11388 1/20 0.54
NPC1 O15118 5/20 0.53
RAB9A P51151 5/20 0.53
MAPT P10636 4/20 0.53
HPGD P15428 4/20 0.53
KDM4E B2RXH2 3/20 0.53
ALDH1A1 P00352 3/20 0.53
HSD17B10 Q99714 3/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
TP53 P04637 1/20 0.53
GLA P06280 1/20 0.53
GAA P10253 1/20 0.53
PKM P14618 1/20 0.53
CASP1 P29466 1/20 0.53
CASP7 P55210 1/20 0.53
KDM6B O15054 1/20 0.53
KDM6A O15550 1/20 0.53
USP2 O75604 1/20 0.51
TDP1 Q9NUW8 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29504749 0.86 TOP2A (0.62) PTGS2TOP2ANPC1RAB9AMAPT
SCHEMBL171055 0.86 TOP2A (0.62) PTGS2TOP2ANPC1RAB9AMAPT
SCHEMBL12854009 0.84 TOP2A (0.60) PTGS2TOP2ANPC1RAB9AMAPT
SCHEMBL13490141 0.83 PTGS2 (0.58) PTGS2TOP2ANPC1RAB9AMAPT
SCHEMBL5051762 0.81 TOP2A (0.59) PTGS2TOP2ANPC1RAB9AMAPT
SCHEMBL5051758 0.79 PTGS2 (0.50) PTGS2TOP2ANPC1RAB9AMAPT
SCHEMBL21742667 0.78 NPC1 (0.59) PTGS2TOP2ANPC1RAB9AMAPT
SCHEMBL29181640 0.78 TOP2A (0.72) PTGS2TOP2ANPC1RAB9AMAPT
SCHEMBL30892595 0.78 TOP2A (0.72) PTGS2TOP2ANPC1RAB9AMAPT
SCHEMBL504406 0.78 PTGS2 (0.55) PTGS2TOP2ANPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4241111-A None JP disclosed
JP-H04241111-A ANISOTROPIC SPIN DOPE OF REDUCED VISCOSITY E I DU PONT DE NEMOURS & CO 1992-08-28 JP disclosed