Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL5863172 | 0.92 | TDP1 (0.48) | TDP1TSHRALDH1A1CYP2C9CYP2C19 | |
| Acetic Acid SCHEMBL3260807 | 0.92 | TDP1 (0.48) | TDP1TSHRALDH1A1CYP2C9CYP2C19 | |
| Carbamic Acid SCHEMBL15212189 | 0.92 | TDP1 (0.48) | TDP1TSHRALDH1A1CYP2C9CYP2C19 | |
| Glycine SCHEMBL149185 | 0.90 | GLRA1 (0.48) | TDP1TSHRALDH1A1CYP2C9CYP2C19 | |
| Urea SCHEMBL2672240 | 0.90 | TDP1 (0.50) | TDP1TSHRALDH1A1CYP2C9CYP2C19 | |
| Glycolic Acid SCHEMBL4565840 | 0.88 | TDP1 (0.45) | TDP1TSHRALDH1A1CYP2C9CYP2C19 | |
| Propionic Acid SCHEMBL27996411 | 0.88 | FFAR3 (0.46) | TDP1TSHRALDH1A1CYP2C9CYP2C19 | |
| Maleic Acid SCHEMBL27863762 | 0.86 | TDP1 (0.43) | TDP1TSHRALDH1A1CYP2C9CYP2C19 | |
| Adipic Acid SCHEMBL1006656 | 0.86 | NFKB1 (0.62) | TSHRALDH1A1LMNATHRBBLM | |
| SCHEMBL30161 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4065416-A | — | — | None | — | — | JP | disclosed |
| US-20240279420-A1 | POLYOL BLENDED LIQUID COMPOSITION FOR PRODUCTION OF HYDROCHLOROFLUOROOLEFIN BLOWN POLYURETHANE FOAM, AND ITS APPLICATION | TOSOH CORPORATION (JP) | 2024-08-22 | — | — | US | disclosed |
| WO-2022239734-A1 | POLYOL-BASED MIXED LIQUID COMPOSITION FOR PRODUCING HYDROCHLOROFUROOLEFIN FOAMED POLYURETHANE FOAM, AND USE THEREOF | 東ソー株式会社 | 2022-11-17 | — | — | WO | disclosed |
| JP-H0465416-A | CATALYST FOR FOAMED URETHANE | SAN APURO KK | 1992-03-02 | — | — | JP | disclosed |
| JP-H00465416-A | — | — | 0001-01-01 | — | — | JP | disclosed |