SCHEMBL9618331

SCHEMBL9618331

COc1ccc(OC(=O)NNc2ccc(Cl)cc2)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 4/20 0.68
MEN1 O00255 4/20 0.52
KMT2A Q03164 4/20 0.52
NPC1 O15118 4/20 0.52
HPGD P15428 1/20 0.51
ALDH1A1 P00352 7/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
SMN1; SMN2 Q16637 6/20 0.50
GAA P10253 4/20 0.50
HTT P42858 1/20 0.50
MAPT P10636 4/20 0.49
RAB9A P51151 3/20 0.49
LMNA P02545 2/20 0.49
P2RX7 Q99572 1/20 0.49
TP53 P04637 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
PKM P14618 1/20 0.49
TSHR P16473 1/20 0.49
NFKB1 P19838 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2829063 1.00 PTGS2 (0.68) PTGS2MEN1KMT2ANPC1HPGD
SCHEMBL14108086 0.86 PTGS2 (0.65) PTGS2MEN1KMT2ANPC1HPGD
SCHEMBL3786216 0.84 SMN1; SMN2 (0.71) PTGS2MEN1KMT2ANPC1HPGD
SCHEMBL1504425 0.84 PTGS2 (0.58) PTGS2MEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL2237027 0.81 PTGS2 (0.58) PTGS2NPC1ALDH1A1SMN1; SMN2GAA
SCHEMBL11566397 0.81 PTGS2 (1.00) PTGS2MEN1KMT2ANPC1HPGD
Hydrochloric Acid SCHEMBL11567963 0.80 PTGS2 (0.97) PTGS2MEN1KMT2ANPC1HPGD
SCHEMBL2829632 0.77 MEN1 (0.46) PTGS2MEN1KMT2ANPC1HPGD
SCHEMBL20984200 0.76 PTGS2 (0.64) PTGS2MEN1KMT2ANPC1HPGD
SCHEMBL6202766 0.76 HPGD (0.66) PTGS2MEN1KMT2ANPC1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4327508-A None JP disclosed
JP-H04327508-A INDUSTRIAL DISINFECTANT TOSOH CORP 1992-11-17 JP disclosed