Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1702139 | 0.88 | ABCB1 (0.65) | LMNAMAPTPOLBNPSR1ABCB1 | |
| Water SCHEMBL51537 | 0.87 | ABCB1 (0.64) | LMNAMAPTPOLBNPSR1ABCB1 | |
| SCHEMBL2277722 | 0.87 | ABCB1 (0.67) | LMNAMAPTPOLBNPSR1ABCB1 | |
| Water SCHEMBL8631908 | 0.85 | ABCB1 (0.65) | LMNAMAPTPOLBNPSR1ABCB1 | |
| SCHEMBL14189198 | 0.77 | USP2 (0.68) | LMNAMAPTPOLBNPSR1USP2 | |
| SCHEMBL14901481 | 0.76 | POLB (0.67) | LMNAMAPTPOLBNPSR1ABCB1 | |
| Hydrochloric Acid SCHEMBL9619106 | 0.76 | ABCB1 (0.61) | LMNAABCB1MAPK1 | |
| SCHEMBL14901508 | 0.76 | LMNA (0.61) | LMNAMAPTPOLBNPSR1ABCB1 | |
| SCHEMBL14904929 | 0.74 | LMNA (0.59) | LMNAMAPTPOLBNPSR1ABCB1 | |
| SCHEMBL18543110 | 0.74 | ABCB1 (0.71) | LMNAMAPTPOLBNPSR1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279475-B1 | BENZOPHENONE DERIVATIVES | WARD BLENKINSOP AND COMPANY LIMITED (GB) | 1992-01-15 | — | — | EP | disclosed |
| EP-0279475-A2 | Benzophenone derivatives | WARD BLENKINSOP AND COMPANY LIMITED (GB) | 1988-08-24 | — | — | EP | disclosed |