SCHEMBL9620281

SCHEMBL9620281

CCC(=O)C1C(=O)CC(c2ccnn2C)CC1=O

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 2/20 0.47
LMNA P02545 2/20 0.35
HDAC4 P56524 2/20 0.34
PRMT5 O14744 1/20 0.32
WDR77 Q9BQA1 1/20 0.32
KMT2A Q03164 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HTT P42858 1/20 0.31
RAB9A P51151 1/20 0.30
PIK3CD O00329 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9620236 0.76 SMN1; SMN2 (0.34) LMNAKMT2ASMN1; SMN2
SCHEMBL9620247 0.76 HCAR2 (0.41) HCAR2LMNAHDAC4PRMT5WDR77
SCHEMBL9620134 0.74 HCAR2 (0.34) HCAR2
SCHEMBL9620124 0.74 HCAR2 (0.34) HCAR2
SCHEMBL9620128 0.74 HCAR2 (0.34) HCAR2
Propionic Acid SCHEMBL9620245 0.74 HCAR2 (0.44) HCAR2LMNAHDAC4PRMT5WDR77
SCHEMBL23278388 0.74 HCAR2 (0.38) HCAR2LMNAKMT2AL3MBTL1SMN1; SMN2
SCHEMBL22572031 0.74 HCAR2 (0.38) HCAR2LMNAKMT2AL3MBTL1SMN1; SMN2
Propionic Acid SCHEMBL10569620 0.73 HCAR2 (0.44) HCAR2LMNAHDAC4PRMT5WDR77
SCHEMBL10359523 0.73 ALDH1A1 (0.39) KMT2AL3MBTL1SMN1; SMN2HTTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0292122-B1 CYCLOHEXADIONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND SELECTIVE HERBICIDAL COMPOSITIONS AS WELL AS HERBICIDAL METHOD NIHON NOHYAKU CO., LTD. (JP) 1992-01-08 EP claimed
EP-0292122-A1 Cyclohexadione derivatives, process for preparing the same and selective herbicidal compositions as well as herbicidal method NIHON NOHYAKU CO., LTD. (JP) 1988-11-23 EP claimed
JP-1193250-A None JP disclosed
EP-0292122-B1 CYCLOHEXADIONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND SELECTIVE HERBICIDAL COMPOSITIONS AS WELL AS HERBICIDAL METHOD NIHON NOHYAKU CO., LTD. (JP) 1992-01-08 EP disclosed
US-4863504-A PLANT GROWTH REGULATORS NIHON NOHYAKU CO., LTD. (JP) 1989-09-05 US disclosed
JP-H01193250-A 1,3-CYCLOHEXANEDIONE DERIVATIVE AND PRODUCTION THEREOF NIPPON NOHYAKU CO LTD 1989-08-03 JP disclosed
EP-0292122-A1 Cyclohexadione derivatives, process for preparing the same and selective herbicidal compositions as well as herbicidal method NIHON NOHYAKU CO., LTD. (JP) 1988-11-23 EP disclosed