Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9620586 | 0.93 | ALDH1A1 (0.42) | ALDH1A1LMNATP53SMN1; SMN2CHRM2 | |
| SCHEMBL9620371 | 0.90 | ALDH1A1 (0.46) | ALDH1A1LMNATP53SMN1; SMN2CHRM2 | |
| SCHEMBL8690403 | 0.89 | ALDH1A1 (0.49) | ALDH1A1LMNATP53SMN1; SMN2CHRM2 | |
| SCHEMBL7968296 | 0.85 | ALDH1A1 (0.40) | ALDH1A1LMNATP53SMN1; SMN2CHRM2 | |
| SCHEMBL8550089 | 0.85 | ALDH1A1 (0.42) | ALDH1A1LMNATP53SMN1; SMN2CHRM2 | |
| SCHEMBL8346740 | 0.85 | ALDH1A1 (0.43) | ALDH1A1LMNATP53SMN1; SMN2CHRM2 | |
| SCHEMBL8546039 | 0.85 | ALDH1A1 (0.43) | ALDH1A1LMNATP53SMN1; SMN2CHRM2 | |
| SCHEMBL8550504 | 0.84 | ALDH1A1 (0.43) | ALDH1A1LMNATP53SMN1; SMN2CHRM2 | |
| SCHEMBL7977970 | 0.82 | ALDH1A1 (0.42) | ALDH1A1LMNATP53SMN1; SMN2CHRM2 | |
| SCHEMBL9620432 | 0.82 | ALDH1A1 (0.45) | ALDH1A1LMNATP53SMN1; SMN2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3008055-B1 | TETRAZOLONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-07-19 | — | — | EP | claimed |
| EP-3008055-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-04-20 | — | — | EP | claimed |
| US-20160083357-A1 | NOVEL TETRAZOLONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-03-24 | — | — | US | claimed |
| WO-2014198592-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-12-18 | — | — | WO | claimed |
| EP-0202929-B1 | SUBSTITUTED TETRAZOLINONES | UNIROYAL CHEMICAL COMPANY, Inc. (US) | 1992-01-02 | — | — | EP | claimed |
| EP-0202929-A2 | Substituted tetrazolinones | UNIROYAL CHEMICAL COMPANY, Inc. (US) | 1986-11-26 | — | — | EP | claimed |
| EP-3008055-B1 | TETRAZOLONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-07-19 | — | — | EP | disclosed |
| EP-3008055-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-04-20 | — | — | EP | disclosed |
| US-20160083357-A1 | NOVEL TETRAZOLONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-03-24 | — | — | US | disclosed |
| WO-2014198592-A1 | NOVEL TETRAZOLONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-12-18 | — | — | WO | disclosed |
| EP-0202929-B1 | SUBSTITUTED TETRAZOLINONES | UNIROYAL CHEMICAL COMPANY, Inc. (US) | 1992-01-02 | — | — | EP | disclosed |
| US-4956469-A | REACTION OF A TETRAZOLONE WITH AN ALKALI METAL CARBONATE FOLLOWED BY REACTION WITH A CARBAMOYL HALIDE, THESE ARE USEFUL AS HERBICIDES | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1990-09-11 | — | — | US | disclosed |
| US-4826529-A | PLANT GROWTH REGULATORS | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0202929-A2 | Substituted tetrazolinones | UNIROYAL CHEMICAL COMPANY, Inc. (US) | 1986-11-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083357-A1 | NOVEL TETRAZOLONE DERIVATIVES | TBXA2R, CYP11B2, NR1I2 | ALDH1A1 143/4885LMNA 3112/4885TP53 3289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.