Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10701176 | 0.96 | KDM4E (0.50) | KDM4EALDH1A1HPGDACHEPARP1 | |
| SCHEMBL10864144 | 0.75 | KDM4E (0.59) | KDM4EALDH1A1HPGDACHEPARP1 | |
| SCHEMBL15911111 | 0.75 | ADRA1A (0.46) | SIRT1CYP1A2ADRA1A | |
| SCHEMBL9620722 | 0.74 | ACHE (0.48) | ACHE | |
| SCHEMBL6379088 | 0.74 | ACHE (0.62) | KDM4EALDH1A1HPGDACHEMAPT | |
| SCHEMBL7772416 | 0.74 | KDM4E (0.62) | KDM4EACHEMAPTLMNAPOLB | |
| SCHEMBL8959962 | 0.73 | KDM4E (0.58) | KDM4EALDH1A1HPGDACHEPARP1 | |
| SCHEMBL559163 | 0.73 | PARP1 (0.47) | KDM4EALDH1A1HPGDACHEPARP1 | |
| SCHEMBL11720868 | 0.73 | LMNA (0.71) | KDM4EALDH1A1HPGDACHEMAPT | |
| SCHEMBL6839377 | 0.73 | KDM4E (0.57) | KDM4EALDH1A1HPGDACHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284359-B1 | 1,4-DISUBSTITUTED PIPERAZINE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-01-08 | — | — | EP | disclosed |
| US-4880809-A | HYPOTENSIVE AGENTS, AMIDE DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0284359-A1 | 1,4-Disubstituted piperazine compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1988-09-28 | — | — | EP | disclosed |