Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 5/20 | 0.31 |
| ▸ | HTR2B | P41595 | 5/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9620992 | 0.94 | HTR2A (0.33) | MAPTHSD17B10KDM4EALDH1A1PDE4B | |
| SCHEMBL9620752 | 0.90 | PDE4B (0.34) | MAPTHSD17B10KDM4EALDH1A1MEN1 | |
| SCHEMBL9620907 | 0.88 | ACHE (0.41) | MAPTHSD17B10KDM4EALDH1A1MEN1 | |
| SCHEMBL10345463 | 0.87 | KDM4E (0.34) | KDM4EALDH1A1POLBGLAMAOA | |
| SCHEMBL9620922 | 0.85 | PDE4B (0.41) | MAPTHSD17B10KDM4EALDH1A1PDE4B | |
| SCHEMBL9620956 | 0.84 | HTR2A (0.32) | PDE4BHTR2CHTR2BHTR2A | |
| SCHEMBL9621094 | 0.80 | HTR2A (0.39) | KDM4EALDH1A1PDE4BGLAMAOA | |
| SCHEMBL9620977 | 0.79 | MAOA (0.47) | MAPTKDM4EALDH1A1MEN1GAA | |
| SCHEMBL9621237 | 0.79 | ACHE (0.39) | MAPTKDM4EALDH1A1POLBGAA | |
| SCHEMBL9621104 | 0.78 | SLC2A1 (0.40) | MAPTHSD17B10KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284359-B1 | 1,4-DISUBSTITUTED PIPERAZINE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-01-08 | — | — | EP | disclosed |
| US-4997836-A | Inhibitor of platelet activating factor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-03-05 | — | — | US | disclosed |
| EP-0369810-A2 | PAF antagonists as anti-hyperendothelinemia agents | Takeda Chemical Industries, Ltd. (JP) | 1990-05-23 | — | — | EP | disclosed |
| EP-0368670-A1 | Trisubstituted piperazine compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-05-16 | — | — | EP | disclosed |
| US-4880809-A | HYPOTENSIVE AGENTS, AMIDE DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0284359-A1 | 1,4-Disubstituted piperazine compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1988-09-28 | — | — | EP | disclosed |