Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 13/20 | 0.42 |
| ▸ | MAOA | P21397 | 12/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17043171 | 0.90 | BRD4 (0.41) | HSD17B1MAPK1MAOB | |
| SCHEMBL9620680 | 0.87 | ACHE (0.51) | HSD17B1MEN1MAPK1KMT2ANPSR1 | |
| SCHEMBL11811840 | 0.82 | BRD4 (0.46) | MAOB | |
| SCHEMBL8712272 | 0.81 | HSD17B1 (0.46) | HSD17B1MEN1MAPK1KMT2ANPSR1 | |
| SCHEMBL1545212 | 0.81 | HSD17B1 (0.46) | HSD17B1MEN1MAPK1KMT2ANPSR1 | |
| SCHEMBL19558961 | 0.78 | MAOB (0.63) | MAOBMAOA | |
| SCHEMBL6825904 | 0.78 | MAOB (0.67) | MAOBMAOA | |
| SCHEMBL424613 | 0.78 | HSD17B1 (0.54) | HSD17B1MEN1MAPK1KMT2ANPSR1 | |
| SCHEMBL3082824 | 0.76 | ACHE (0.54) | HSD17B1KMT2AMAOB | |
| SCHEMBL3965311 | 0.75 | MAOB (0.38) | MEN1KMT2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284359-B1 | 1,4-DISUBSTITUTED PIPERAZINE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-01-08 | — | — | EP | disclosed |
| US-4880809-A | HYPOTENSIVE AGENTS, AMIDE DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0284359-A1 | 1,4-Disubstituted piperazine compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1988-09-28 | — | — | EP | disclosed |