Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29569289 | 0.80 | TSHR (0.51) | CTNNB1TSHRCDC7DBF4 | |
| SCHEMBL9621611 | 0.80 | TSHR (0.51) | CTNNB1TSHRCDC7DBF4 | |
| SCHEMBL9621704 | 0.73 | MAP3K7 (0.35) | ADORA3ADORA2B | |
| SCHEMBL735449 | 0.71 | NOTUM (0.60) | NOTUMTSHR | |
| SCHEMBL2888984 | 0.69 | G6PD (0.48) | NOTUMTSHRCDC7DBF4 | |
| SCHEMBL13401493 | 0.68 | SLC6A5 (0.47) | NOTUMTSHR | |
| SCHEMBL14347081 | 0.66 | SLC6A5 (0.54) | NOTUMCTNNB1TSHRCDC7DBF4 | |
| SCHEMBL9177267 | 0.66 | NOTUM (0.41) | NOTUMCTNNB1TSHRCDC7DBF4 | |
| SCHEMBL240979 | 0.66 | TP53 (0.52) | NOTUMTSHRCDC7DBF4 | |
| SCHEMBL1884552 | 0.66 | G6PD (0.37) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186454-B1 | 6-PURINYL N-(2-CHLOROETHYL) CARBAMATE AND THIOCARBAMATE, A PROCESS FOR THEIR PREPARATION AND USE THEREOF | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) | 1992-04-08 | — | — | EP | claimed |
| US-4720497-A | 6-purinyl N-/2-chloroethyl/carbamate and thiocarbamate and process for the preparation thereof | SPOFA, SPOJENE PODNIKY PRO ZDRAVOTNICKOU VYROBU (CS) | 1988-01-19 | — | — | US | claimed |
| US-4720497-A | 6-purinyl N-/2-chloroethyl/carbamate and thiocarbamate and process for the preparation thereof | SPOFA, SPOJENE PODNIKY PRO ZDRAVOTNICKOU VYROBU (CS) | 1988-01-19 | — | — | US | disclosed |