Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 4/20 | 0.71 |
| ▸ | DHCR7 | Q9UBM7 | 4/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.71 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17007504 | 0.84 | EBP (1.00) | EBPDHCR7NPC1NPSR1EPHX2 | |
| SCHEMBL17007435 | 0.84 | EBP (1.00) | EBPDHCR7NPC1NPSR1EPHX2 | |
| SCHEMBL22834209 | 0.83 | NPSR1 (0.69) | EBPDHCR7NPC1NPSR1EPHX2 | |
| SCHEMBL17007461 | 0.82 | EBP (0.97) | EBPDHCR7NPC1NPSR1EPHX2 | |
| SCHEMBL7076796 | 0.81 | NPSR1 (0.67) | EBPDHCR7NPC1NPSR1EPHX2 | |
| SCHEMBL29483654 | 0.81 | NPSR1 (0.67) | EBPDHCR7NPC1NPSR1ALDH1A1 | |
| SCHEMBL17007406 | 0.81 | NPSR1 (0.67) | EBPDHCR7NPC1NPSR1EPHX2 | |
| SCHEMBL14411560 | 0.80 | PKM (0.59) | EBPDHCR7NPC1NPSR1ALDH1A1 | |
| SCHEMBL18711514 | 0.78 | ALDH1A1 (0.71) | EBPDHCR7NPC1NPSR1EPHX2 | |
| SCHEMBL22033211 | 0.77 | EPHX2 (0.68) | EBPDHCR7NPC1NPSR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105873913-B | Therapeutics targeting truncated Adenomatous Polyposis Coli (APC) proteins | 得克萨斯系统大学评议会 | 2019-12-03 | — | — | CN | disclosed |
| EP-0254158-B1 | PYRIMIDIN DERIVATIVES AND PROCESS FOR THEIR PREPARATION | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1992-01-29 | — | — | EP | disclosed |
| US-4960888-A | Preparation of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine compounds | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1990-10-02 | — | — | US | disclosed |
| EP-0254158-A2 | Pyrimidin derivatives and process for their preparation | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1988-01-27 | — | — | EP | disclosed |
| EP-0252515-A1 | Process for the preparation of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidino-pyrimidine | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1988-01-13 | — | — | EP | disclosed |