Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 7/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | ACE | P12821 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | ECE1 | P42892 | 1/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9622300 | 1.00 | MME (0.72) | MMEALDH1A1ACEHPGDMAPK1 | |
| SCHEMBL10447979 | 0.90 | MME (0.81) | MMEALDH1A1ACEHPGDMAPK1 | |
| SCHEMBL7103054 | 0.85 | MME (0.74) | MMEALDH1A1ACEHPGDMAPK1 | |
| SCHEMBL825762 | 0.85 | MME (0.74) | MMEALDH1A1ACEHPGDMAPK1 | |
| SCHEMBL10396440 | 0.84 | ACE (0.77) | MMEACE | |
| SCHEMBL7432078 | 0.84 | ACE (0.77) | MMEACE | |
| SCHEMBL7432071 | 0.84 | ACE (0.77) | MMEACE | |
| SCHEMBL10396439 | 0.84 | ACE (0.77) | MMEACE | |
| SCHEMBL7437961 | 0.84 | ACE (0.77) | MMEACE | |
| (R)-Thiorphan SCHEMBL7312756 | 0.84 | MME (1.00) | MMEALDH1A1ACEHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166212-A | Hypotensive agents, analgesics | CIBA-GEIGY CORPORATION (US) | 1992-11-24 | — | — | US | disclosed |
| US-5021430-A | Enkephalinase inhibitors, analgesics, hypotensives | CIBA-GEIGY CORPORATION (US) | 1991-06-04 | — | — | US | disclosed |
| EP-0225292-A2 | Certain N-substituted butyramide derivatives | CIBA-GEIGY AG (CH) | 1987-06-10 | — | — | EP | disclosed |