Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 9/20 | 0.74 |
| ▸ | ACE | P12821 | 4/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | ECE1 | P42892 | 2/20 | 0.74 |
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | BLM | P54132 | 1/20 | 0.74 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7103054 | 1.00 | MME (0.74) | MMEACEALDH1A1ECE1HPGD | |
| SCHEMBL10447979 | 0.91 | MME (0.81) | MMEACEALDH1A1ECE1HPGD | |
| Thiorphan SCHEMBL401174 | 0.85 | MME (1.00) | MMEACEALDH1A1ECE1HPGD | |
| SCHEMBL9622300 | 0.85 | MME (0.72) | MMEACEALDH1A1ECE1HPGD | |
| (R)-Thiorphan SCHEMBL7312756 | 0.85 | MME (1.00) | MMEACEALDH1A1ECE1HPGD | |
| (S)-Thiorphan SCHEMBL49662 | 0.85 | MME (1.00) | MMEACEALDH1A1ECE1HPGD | |
| SCHEMBL9622302 | 0.85 | MME (0.72) | MMEACEALDH1A1ECE1HPGD | |
| SCHEMBL10691553 | 0.84 | MME (0.70) | MMEACEALDH1A1ECE1HPGD | |
| SCHEMBL19437143 | 0.84 | MME (0.70) | MMEACEALDH1A1ECE1HPGD | |
| SCHEMBL7107731 | 0.82 | CYP1A2 (0.70) | MMEACEALDH1A1ECE1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011161646-A3 | PROCESS FOR THE PREPARATION OF ALVIMOPAN OR ITS PHARMACEUTICALLY ACCEPTABLE SALT OR SOLVATE THEREOF | RANBAXY LABORATORIES LIMITED (IN) | 2012-03-15 | — | — | WO | disclosed |
| WO-2011161646-A2 | PROCESS FOR THE PREPARATION OF ALVIMOPAN OR ITS PHARMACEUTICALLY ACCEPTABLE SALT OR SOLVATE THEREOF | RANBAXY LABORATORIES LIMITED (IN) | 2011-12-29 | — | — | WO | disclosed |