Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 9/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 4/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487514 | 0.86 | SMN1; SMN2 (0.40) | CTSKCA1CA2CA7CYP2D6 | |
| SCHEMBL7346754 | 0.85 | CA1 (0.38) | CTSKCA1CA2CA7CYP2D6 | |
| SCHEMBL4520424 | 0.85 | CA1 (0.38) | CTSKCA1CA2CA7CYP2D6 | |
| SCHEMBL1262397 | 0.85 | CA1 (0.38) | CTSKCA1CA2CA7CYP2D6 | |
| SCHEMBL1861342 | 0.82 | CA1 (0.40) | CTSKCA1CA2CA7CYP2D6 | |
| SCHEMBL3227264 | 0.82 | CA1 (0.40) | CTSKCA1CA2CA7CYP2D6 | |
| SCHEMBL1861340 | 0.82 | CA1 (0.40) | CTSKCA1CA2CA7CYP2D6 | |
| SCHEMBL28343011 | 0.81 | CTSK (0.43) | CTSKCA1CA2CA7CYP2D6 | |
| SCHEMBL28343009 | 0.81 | CTSK (0.43) | CTSKCA1CA2CA7CYP2D6 | |
| SCHEMBL3613413 | 0.81 | CA1 (0.39) | CTSKCA1CA2CA7CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4588825-A | Intermediates for the synthesis of 4-amino-4,5-dihydro-2-furancarboxylic acid | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-05-13 | — | — | US | claimed |
| EP-0145875-A2 | Gamma-aminobutyric acid transaminase inhibitors and processes for their preparation | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-06-26 | — | — | EP | claimed |
| EP-0145875-B1 | GAMMA-AMINOBUTYRIC ACID TRANSAMINASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-02-19 | — | — | EP | disclosed |
| US-4824974-A | Synthesis for the preparation of 4-amino-4,5-dihydro-2-furancarboxylic acid | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-04-25 | — | — | US | disclosed |
| US-4588825-A | Intermediates for the synthesis of 4-amino-4,5-dihydro-2-furancarboxylic acid | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-05-13 | — | — | US | disclosed |
| EP-0145875-A2 | Gamma-aminobutyric acid transaminase inhibitors and processes for their preparation | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-06-26 | — | — | EP | disclosed |