SCHEMBL9623391

SCHEMBL9623391

C[C@]12CCC3(CC1=CC[C@@H]1C2=CC[C@@]2(C)[C@H]1CC[C@@]2(C#N)O[Si](C)(C)CCl)OCCO3

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.35
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9624222 0.92 POLB (0.35) POLBMAPT
SCHEMBL9624226 0.88 POLB (0.35) POLBMAPT
SCHEMBL9624018 0.78 POLB (0.52) POLBMAPT
SCHEMBL9623675 0.78 NR3C1 (0.33)
SCHEMBL16016531 0.76
SCHEMBL9623719 0.71 NR3C1 (0.32)
SCHEMBL9623546 0.70 NR3C1 (0.34)
SCHEMBL9623918 0.70 POLB (0.52) POLBMAPT
SCHEMBL9623549 0.70 POLB (0.52) POLBMAPT
SCHEMBL11778305 0.68 POLB (0.59) POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0268400-B1 STEROIDAL 17ALPHA-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGESTERONES THE UPJOHN COMPANY (US) 1992-04-29 EP claimed