Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 13/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1157695 | 0.97 | RAPGEF4 (0.50) | RAPGEF4ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL23578512 | 0.84 | RAPGEF4 (0.42) | RAPGEF4ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL18462944 | 0.84 | RAPGEF4 (0.45) | RAPGEF4ALDH1A1TSHRCYP1A2CYP2A6 | |
| SCHEMBL26194225 | 0.84 | RAPGEF4 (0.45) | RAPGEF4ALDH1A1TSHRCYP1A2CYP2A6 | |
| SCHEMBL3873048 | 0.84 | ALDH1A1 (0.50) | RAPGEF4ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL5553797 | 0.82 | RAPGEF4 (0.43) | RAPGEF4ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL12938568 | 0.82 | RAPGEF4 (0.39) | RAPGEF4 | |
| SCHEMBL27170430 | 0.82 | RAPGEF4 (0.41) | RAPGEF4ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL85680 | 0.80 | RAPGEF4 (0.42) | RAPGEF4CYP1A2CYP2A6FFAR4TP53 | |
| SCHEMBL13456155 | 0.80 | FFAR4 (0.46) | RAPGEF4ALDH1A1KDM4ETSHRFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268400-B1 | STEROIDAL 17ALPHA-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGESTERONES | THE UPJOHN COMPANY (US) | 1992-04-29 | — | — | EP | disclosed |
| US-4977255-A | Steroidal 17α-silyl ethers and process to corticoids and progesterones | THE UPJOHN COMPANY (US) | 1990-12-11 | — | — | US | disclosed |
| US-4921638-A | 17β-cyano-9α,17α-dihydroxyandrost-4-en-3-one | THE UPJOHN COMPANY (US) | 1990-05-01 | — | — | US | disclosed |
| EP-0334875-A1 | STEROIDAL 17$g(a)-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGGESTERONES | THE UPJOHN COMPANY (US) | 1989-10-04 | — | — | EP | disclosed |
| EP-0268400-A1 | Steroidal 17alpha-silyl ethers and process to corticoids and progesterones | THE UPJOHN COMPANY (US) | 1988-05-25 | — | — | EP | disclosed |
| WO-1988003534-A1 | STEROIDAL 17alpha-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGGESTERONES | THE UPJOHN COMPANY (US) | 1988-05-19 | — | — | WO | disclosed |