Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 12/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.31 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9623855 | 0.91 | SRD5A2 (0.37) | ESR1ARESR2SRD5A2CYP19A1 | |
| SCHEMBL9623923 | 0.91 | SRD5A2 (0.37) | ESR1ARESR2SRD5A2CYP19A1 | |
| SCHEMBL9623276 | 0.78 | HIF1A (0.33) | AR | |
| SCHEMBL9623848 | 0.78 | SRD5A2 (0.44) | ESR1ARESR2SRD5A2 | |
| SCHEMBL9623162 | 0.77 | SHBG (0.54) | ESR1ARCYP19A1 | |
| SCHEMBL9623918 | 0.77 | POLB (0.52) | CYP19A1 | |
| SCHEMBL3749381 | 0.72 | SRD5A2 (0.39) | ESR1ARESR2SRD5A2CYP19A1 | |
| SCHEMBL9806099 | 0.72 | SHBG (0.56) | ESR1ARESR2 | |
| SCHEMBL10898740 | 0.72 | SHBG (0.56) | ESR1ARESR2 | |
| SCHEMBL3754980 | 0.72 | ESR1 (0.37) | ESR1ARESR2SRD5A2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268400-B1 | STEROIDAL 17ALPHA-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGESTERONES | THE UPJOHN COMPANY (US) | 1992-04-29 | — | — | EP | claimed |
| EP-0334875-A1 | STEROIDAL 17$g(a)-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGGESTERONES | THE UPJOHN COMPANY (US) | 1989-10-04 | — | — | EP | claimed |
| EP-0268400-A1 | Steroidal 17alpha-silyl ethers and process to corticoids and progesterones | THE UPJOHN COMPANY (US) | 1988-05-25 | — | — | EP | claimed |
| WO-1988003534-A1 | STEROIDAL 17alpha-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGGESTERONES | THE UPJOHN COMPANY (US) | 1988-05-19 | — | — | WO | claimed |