Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 11/20 | 0.67 |
| ▸ | PGR | P06401 | 6/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | TNF | P01375 | 1/20 | 0.67 |
| ▸ | IL6 | P05231 | 1/20 | 0.67 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.67 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.67 |
| ▸ | AR | P10275 | 1/20 | 0.67 |
| ▸ | GLUL | P15104 | 1/20 | 0.67 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.67 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11401828 | 0.86 | NR3C1 (0.73) | NR3C1PGRHIF1AHSD17B10ABCB11 | |
| SCHEMBL22368058 | 0.86 | NR3C1 (0.73) | NR3C1PGRHIF1AHSD17B10ABCB11 | |
| SCHEMBL18919491 | 0.86 | NR3C1 (0.73) | NR3C1PGRHIF1AHSD17B10ABCB11 | |
| SCHEMBL8939666 | 0.84 | LMNA (0.73) | NR3C1PGRHIF1AHSD17B10CYP3A4 | |
| Loteprednol SCHEMBL23974936 | 0.82 | NR3C1 (0.80) | NR3C1PGRHIF1AHSD17B10ABCB11 | |
| Deprodone SCHEMBL121194 | 0.82 | NR3C1 (0.80) | NR3C1PGRHIF1AHSD17B10ABCB11 | |
| Loteprednol SCHEMBL12738241 | 0.82 | NR3C1 (0.80) | NR3C1PGRHIF1AHSD17B10ABCB11 | |
| Loteprednol SCHEMBL15803210 | 0.82 | NR3C1 (0.80) | NR3C1PGRHIF1AHSD17B10ABCB11 | |
| Loteprednol SCHEMBL5095876 | 0.82 | NR3C1 (0.80) | NR3C1PGRHIF1AHSD17B10ABCB11 | |
| Loteprednol SCHEMBL12396678 | 0.82 | NR3C1 (0.80) | NR3C1PGRHIF1AHSD17B10ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268400-B1 | STEROIDAL 17ALPHA-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGESTERONES | THE UPJOHN COMPANY (US) | 1992-04-29 | — | — | EP | claimed |
| US-4548748-A | Cyanohydrin process | THE UPJOHN COMPANY (US) | 1985-10-22 | — | — | US | claimed |
| US-4831131-A | 11β,17α-Dihydroxy-17β-cyano-androstanes | THE UPJOHN COMPANY (US) | 1989-05-16 | — | — | US | disclosed |
| US-4585590-A | Cyanohydrin process | THE UPJOHN COMPANY (US) | 1986-04-29 | — | — | US | disclosed |
| US-4548748-A | Cyanohydrin process | THE UPJOHN COMPANY (US) | 1985-10-22 | — | — | US | disclosed |
| EP-0153001-A2 | Steroids having an enamide or enimide group and their preparation | THE UPJOHN COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |
| US-4500461-A | Cyanohydrin process | THE UPJOHN COMPANY (US) | 1985-02-19 | — | — | US | disclosed |