Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625948 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2HPGDNPC1ALDH1A1KMT2A | |
| SCHEMBL9625622 | 0.86 | ALDH1A1 (0.68) | HPGDNPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL7437625 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL9864972 | 0.78 | NPC1 (0.67) | HPGDNPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL12082384 | 0.77 | SMN1; SMN2 (0.70) | SMN1; SMN2HPGDNPC1ALDH1A1KMT2A | |
| SCHEMBL22489529 | 0.76 | PANK3 (0.68) | GRIN1GRIN2B | |
| SCHEMBL9625113 | 0.76 | JAK2 (0.63) | SMN1; SMN2HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL28086313 | 0.76 | NPC1 (0.64) | HPGDNPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL7289568 | 0.76 | DPP7 (0.50) | SMN1; SMN2HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL7289575 | 0.76 | DPP7 (0.50) | SMN1; SMN2HPGDALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |