Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624233 | 0.91 | HCN4 (0.39) | MAPTHCN4CYP3A4ALOX15POLB | |
| SCHEMBL9623729 | 0.87 | AOC3 (0.35) | MAPTHCN4CYP3A4ALOX15 | |
| SCHEMBL9624075 | 0.84 | HCN4 (0.39) | MAPTHCN4CYP3A4ALOX15POLB | |
| SCHEMBL9624315 | 0.84 | ALOX15 (0.36) | MAPTHCN4CYP3A4ALOX15HPGD | |
| SCHEMBL9625718 | 0.83 | KDM4E (0.32) | MAPTHCN4CYP3A4ALOX15KDM4E | |
| SCHEMBL9624712 | 0.83 | MAPT (0.35) | MAPTHCN4CYP3A4ALOX15KDM4E | |
| SCHEMBL9625033 | 0.82 | ALDH1A1 (0.37) | MAPTHCN4CYP3A4ALOX15POLB | |
| SCHEMBL9624284 | 0.81 | KDM4E (0.36) | MAPTHCN4CYP3A4ALOX15HPGD | |
| SCHEMBL9623825 | 0.80 | KDM4E (0.36) | MAPTHCN4CYP3A4ALOX15HPGD | |
| SCHEMBL10663933 | 0.79 | HCN4 (0.59) | MAPTHCN4CYP3A4ALOX15POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |