Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 7/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.33 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624233 | 0.89 | HCN4 (0.39) | MAPTHCN4CYP3A4ALOX15 | |
| SCHEMBL9624893 | 0.88 | MAPT (0.40) | AOC3ITGB3ITGA2BMAPTHCN4 | |
| SCHEMBL9624342 | 0.87 | MAPT (0.34) | MAPTHCN4CYP3A4ALOX15 | |
| SCHEMBL9623829 | 0.84 | ITGB3 (0.35) | ITGB3MAPTITGB1ITGAVITGA5 | |
| SCHEMBL9624075 | 0.83 | HCN4 (0.39) | MAPTHCN4CYP3A4ALOX15 | |
| SCHEMBL9624315 | 0.83 | ALOX15 (0.36) | MAPTHCN4CYP3A4ALOX15 | |
| SCHEMBL9625033 | 0.81 | ALDH1A1 (0.37) | MAPTHCN4CYP3A4ALOX15 | |
| SCHEMBL10670584 | 0.80 | HCN4 (0.57) | AOC3ITGB3MAPTHCN4ITGB1 | |
| SCHEMBL9624712 | 0.80 | MAPT (0.35) | MAPTHCN4CYP3A4ALOX15 | |
| SCHEMBL9624306 | 0.80 | HCN4 (0.40) | ITGB3MAPTHCN4ITGB1ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |